Thermo Fisher Scientific CD11b Monoclonal Antibody (VIM12), Alexa Fluor 700
Alexa Fluor 700으로 표지된 인간 CD11b 단클론 항체(VIM12). 유세포분석용으로 최적화되어 있으며, 높은 형광 안정성과 명확한 신호를 제공합니다. PBS/BSA 완충액에 보관되며 4°C 암소 조건에서 안정적입니다. 다양한 세포 표면 마커 연구에 활용 가능.
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Applications
- Flow Cytometry (Flow): Assay-dependent
- View 3 publications
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | VIM12 |
| Immunogen | Human CD11b (Mac-1) |
| Conjugate | Alexa Fluor™ 700 |
| Excitation / Emission Max | 696 / 719 nm |
| Form | Liquid |
| Purification | Purified |
| Storage Buffer | PBS with BSA |
| Contains | 0.1% sodium azide |
| Storage Conditions | 4°C, store in dark |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2536485 |
Additional Formats
Product Specific Information
The Alexa Fluor™ 700 dye conjugate provides an excellent spectral match to common long-wavelength excitation sources and exhibits a high extinction coefficient, ensuring bright and stable fluorescence signals.
Target Information
CD11b (integrin alpha-M, ITGAM, integrin alpha-X, ITGAX) is a 165 kDa adhesion molecule that associates non-covalently with integrin beta-2 (CD18). The CD11b/CD18 heterodimeric complex, also known as integrin alpha-M beta-2, Mac-1, or CR3 (complement receptor 3), is expressed on monocytes/macrophages, granulocytes, activated lymphocytes, subsets of NK cells and dendritic cells, and microglia.
It mediates binding to ICAM-1 (CD54), ICAM-2 (CD102), ICAM-4 (CD242), CD14, CD50, CD23, heparin, iC3b, fibrinogen, and Factor X, playing key roles in cell-cell and cell-matrix interactions.
CD11b expression increases during monocyte maturation and varies among tissue macrophages, being higher in peritoneal macrophages compared to splenic macrophages.
CD11b dysfunction is associated with systemic lupus erythematosus and ITGAM-related susceptibility to autoimmune diseases.
Analyte Specific Reagent
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