Thermo Fisher Scientific TNFR1 Monoclonal Antibody (HM104), FITC
TNFR1의 세포외 도메인을 인식하는 HM104 클론의 Rat 모노클론 항체로, FITC 형광 표지되어 있음. Flow Cytometry, IHC(F), Inhibition Assay 등 다양한 응용에 사용 가능. 4°C 암조건에서 보관하며 Protein G로 정제된 고순도 항체.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Frozen) (IHC (F)) | 1:50 |
| Flow Cytometry (Flow) | 1:50 |
| Inhibition Assays (IA) | 1:50 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Rat / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | HM104 |
| Immunogen | The monoclonal antibody HM104 recognizes the extracellular part of the Tumor Necrosis Factor Receptor type I (TNFR1). |
| Conjugate | FITC |
| Excitation / Emission Max | 498 / 517 nm |
| Form | Liquid |
| Concentration | 100 µg/mL |
| Purification | Protein G |
| Storage Buffer | PBS with 1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | 4°C, store in dark |
| Shipping Conditions | Wet ice |
| RRID | AB_3093286 |
Target Information
TNFR1 (Tumor necrosis factor receptor 1) belongs to the tumor necrosis factor superfamily and is one of the major TNF-alpha receptors.
It plays an important role in cytokine-mediated signaling, positive regulation of the NF-κB pathway, positive regulation of angiogenesis, and negative regulation of gene expression.
The extracellular domain of TNFR1 can be released into circulation as soluble TNFR1 (sTNFR1).
In humans, the TNFR1 gene is located on chromosome 12.
Anti-apoptotic protein BAG4/SODD and adaptor proteins TRADD and TRAF2 interact with TNFR1, playing regulatory roles in signal transduction.
Germline mutations in the extracellular domain are associated with autosomal dominant periodic fever syndrome due to impaired receptor clearance.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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