Thermo Fisher Scientific TNFR2 Monoclonal Antibody (80M2), FITC
인간 TNFR2를 인식하는 단클론 항체로, FITC 형광 표지되어 ICC/IF, Flow Cytometry, IP 등 다양한 실험에 사용 가능. 단백질 G로 정제된 액상 형태이며, 4°C 암조건에서 보관. TNF-α 반응을 강화하는 비작용성 수용체 조절 항체.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunocytochemistry (ICC/IF) | 1:50 |
| Flow Cytometry (Flow) | 1:50 |
| Immunoprecipitation (IP) | 1:50 |
| Functional Assay | 1:50 |
| Inhibition Assay | 1:50 |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 80M2 |
| Immunogen | The monoclonal antibody 80M2 recognizes the extracellular part of membrane-bound TNF-RII |
| Conjugate | FITC |
| Excitation / Emission Max | 498 / 517 nm |
| Form | Liquid |
| Concentration | 100 µg/mL |
| Purification | Protein G |
| Storage Buffer | PBS with 1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | 4°C, store in dark |
| Shipping Conditions | Wet ice |
| RRID | AB_3093260 |
Product Specific Information
The monoclonal antibody 80M2 recognizes the extracellular part of membrane-bound TNF-RII as well as the soluble form generated by proteolytic cleavage of the extracellular domain.
This antibody is a non-agonistic receptor-modulating antibody that enhances in vitro TNF-alpha responses by increasing the affinity of the soluble form of TNF-alpha for TNF-RII.
Target Information
TNFR2 (tumor necrosis factor receptor superfamily member 1B) is a receptor with high affinity for TNFSF2/TNF-alpha and lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha.
The TRAF1/TRAF2 complex recruits apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. TNFR2 mediates most metabolic effects of TNF-alpha.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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