Thermo Fisher Scientific TNFR2 Monoclonal Antibody (80M2), Biotin
TNFR2의 막 결합형 및 가용형 형태를 모두 인식하는 비오틴 결합 단일클론 항체. 비작용성 수용체 조절 항체로 TNF-α 반응을 강화. ICC, Flow, IP, Functional, Inhibition Assay에 적합. 연구용으로만 사용 가능.
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Thermo Fisher Scientific TNFR2 Monoclonal Antibody (80M2), Biotin
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunocytochemistry (ICC/IF) | 1:50 |
| Flow Cytometry (Flow) | 1:50 |
| Immunoprecipitation (IP) | 1:50 |
| Functional Assay | 1:50 |
| Inhibition Assays (IA) | 1:50 |
Product Specifications
| Property | Description |
|---|---|
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 80M2 |
| Immunogen | Recognizes the extracellular part of membrane-bound TNF-RII as well as the soluble form generated by proteolytic cleavage of its extracellular domain |
| Conjugate | Biotin |
| Form | Liquid |
| Concentration | 100 µg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Additional Formats
Product Specific Information
The monoclonal antibody 80M2 recognizes both the membrane-bound and soluble forms of TNF-RII. It is a non-agonistic receptor modulating antibody that enhances in vitro TNF-alpha responses by increasing the affinity of the soluble form of TNF-alpha for TNF-RII.
Target Information
TNFR2 (tumor necrosis factor receptor superfamily member 1B) is a receptor with high affinity for TNFSF2/TNF-alpha and lower affinity for TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. TNFR2 mediates most metabolic effects of TNF-alpha.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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