Thermo Fisher Scientific Livin Polyclonal Antibody
Livin 단백질을 인식하는 Rabbit Polyclonal Antibody로, Western blot, IHC, ICC/IF에 사용 가능. 인간, 마우스, 랫 반응성. 항원 친화 크로마토그래피로 정제된 고순도 제품. 연구용으로만 사용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant full length Human ML-IAP/BIRC7 (Livin, UniProt ID: Q96CA5-1, 1–298 aa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2804010 |
Product Specific Information
Purity is >95% by SDS-PAGE.
Target Information
The inhibitor of apoptosis (IAP) family of proteins regulates programmed cell death triggered by various stimuli. All IAPs have at least one baculovirus IAP repeat (BIR) motif that is essential for their anti-apoptotic activity.
Livin (also known as ML-IAP) is a human IAP family member containing a single BIR domain and a COOH-terminal RING finger domain. The Livin gene has two splicing variants encoding 298 and 280 amino acid isoforms, both containing BIR and RING domains. These isoforms inhibit TNFα-induced apoptosis in Jurkat cells. Livin expression is low in adult tissues but relatively higher in developmental tissues and many cancer cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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