Thermo Fisher Scientific SNAIL Polyclonal Antibody
SNAIL 단백질을 인식하는 Rabbit Polyclonal 항체로, Human, Mouse, Rat에서 반응합니다. Western Blot, IHC, ICC/IF에 사용 가능하며, 고순도(>95%) 항원 친화 크로마토그래피로 정제되었습니다. 액상 형태, 1 mg/mL 농도, 연구용으로만 사용됩니다.
- 카탈로그번호
- PA587258
- 판매단위
- pk
카탈로그
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant full length Human SNAI1 (UniProt ID: O95863-1, Antigen range: 1–264) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term; for long term store at -20°C, avoiding freeze/thaw cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2804005 |
Product Specific Information
Purity is >95% by SDS-PAGE.
Target Information
Zinc finger protein SNAI1 (SNAIL) is a zinc finger transcriptional repressor that downregulates ectodermal gene expression within the mesoderm and plays a role in mesoderm and neural crest formation.
SNAI1 is an important factor in tumor invasion through E-cadherin down-regulation and induction of epithelial-mesenchymal transition (EMT).
In human breast cancer, SNAI1 and/or SNAI2 (Slug) expression is associated with E-cadherin repression, metastasis, tumor recurrence, and poor prognosis.
Snail 1 protein in the stroma may serve as a putative prognostic marker for colon tumors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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