Thermo Fisher Scientific Phospho-c-Met (Tyr1349) Recombinant Rabbit Monoclonal Antibody (JE51-68)
인간 c-Met (Tyr1349) 인산화 부위를 인식하는 재조합 토끼 단클론 항체. Western blot 및 IHC(P) 검증 완료. Protein A 정제, 1 mg/mL 농도의 액상 형태. 종양 연구 및 신호전달 경로 분석에 적합.
- 카탈로그번호
- MA542486
- 판매단위
- pk
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | JE51-68 |
| Immunogen | Synthetic phospho-peptide corresponding to residues surrounding Tyr1349 of human Met |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 40% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2911627 |
Product Specific Information
- Positive Control: Human colon carcinoma tissue, human small intestine tissue, human rectum tissue
- Subcellular Location: Membrane, secreted
Target Information
MET (c-Met) is a receptor-like tyrosine kinase whose dysregulation has been associated with many human cancers. Upon ligand activation, MET interacts with PI3K subunit PIK3R1, PLCG1, SRC, GRB2, and STAT3, leading to activation of signaling cascades such as RAS-ERK, PI3K-AKT, and PLCγ-PKC.
MET is involved in embryonic development processes including gastrulation, muscle and neuron development, angiogenesis, and kidney formation. In adults, it contributes to wound healing, organ regeneration, and tissue remodeling.
Aberrant MET signaling is linked to cancers such as gastric, renal, and breast cancer, making it a key target for cancer research and therapeutic development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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