Thermo Fisher Scientific NR4A2 Monoclonal Antibody (4A6)
NR4A2(Nurr1) 단백질을 인식하는 마우스 모노클로날 항체로, Western blot과 ELISA에 적합합니다. 인간 시료에 반응하며 비결합형 액상 형태로 제공됩니다. 도파민성 신경계 연구 및 파킨슨병 관련 연구에 활용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 4A6 |
| Immunogen | NR4A2 (AAH66890, 71 a.a. approximately 170 a.a) partial recombinant protein with GST tag. MW of GST tag alone is 26 kDa. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Storage Buffer | Ascites |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Protein sequence:
GFQVQHSPMW DDPGSLHNFH QNYVATTHMI EQRKTPVSRL SLFSFKQSPP GTPVSSCQMR FDGPLHVPMN PEPAGSHHVV DGQTFAVPNP IRKPASMGFP
Target Information
The Nuclear receptor related 1 protein (Nurr1), also known as NR4A2 (nuclear receptor subfamily 4, group A, member 2), is a protein encoded by the NR4A2 gene in humans.
NURR1 is a member of the nuclear receptor family of intracellular transcription factors and plays a key role in maintaining the dopaminergic system of the brain.
Mutations in this gene have been associated with dopaminergic dysfunction–related disorders, including Parkinson’s disease, schizophrenia, and manic depression. Misregulation may also be linked to rheumatoid arthritis.
Four transcript variants encoding distinct isoforms have been identified, with possible additional splice variants not yet fully characterized.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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