Thermo Fisher Scientific NR4A2 Monoclonal Antibody (1G6)
NR4A2 단백질을 인식하는 Mouse Monoclonal Antibody (Clone 1G6). Western blot 및 ELISA에 적합하며, 인간 시료에 반응. 뇌 도파민 시스템 관련 연구에 유용. 액상 형태, 보존제 없음, -20°C 보관.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
ELISA
- Tested Dilution: 10 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 1G6 |
| Immunogen | NR4A2 (AAH66890, 71 a.a. ~170 a.a.) partial recombinant protein with GST tag (MW of GST tag alone: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Storage Buffer | Ascites |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
GFQVQHSPMW DDPGSLHNFH QNYVATTHMI EQRKTPVSRL SLFSFKQSPP GTPVSSCQMR FDGPLHVPMN PEPAGSHHVV DGQTFAVPNP IRKPASMGFP
Target Information
The Nuclear receptor related 1 protein (Nurr1), also known as NR4A2 (nuclear receptor subfamily 4, group A, member 2), is encoded by the NR4A2 gene in humans.
NURR1 is a member of the nuclear receptor family of intracellular transcription factors and plays a key role in maintaining the dopaminergic system of the brain.
Mutations in this gene have been linked to disorders related to dopaminergic dysfunction, including Parkinson’s disease, schizophrenia, and manic depression.
Misregulation of this gene may be associated with rheumatoid arthritis.
Four transcript variants encoding distinct isoforms have been identified, and additional alternate splice variants may exist but are not fully characterized.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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