Thermo Fisher Scientific NR4A2 Monoclonal Antibody (4A6)
NR4A2(Nurr1) 단백질을 인식하는 Mouse monoclonal antibody(클론 4A6)로, Western blot, ICC/IF, ELISA에 적합합니다. 인간 시료 반응성이 있으며, PBS buffer에 보관되고 보존제가 없습니다. 도파민 시스템 연구 및 신경질환 관련 연구에 활용 가능합니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–5 µg/mL |
| Immunocytochemistry (ICC/IF) | 10 µg/mL |
| ELISA | 3 ng/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 4A6 |
| Immunogen | NR4A2 (AAH66890, 71 a.a. approximately 170 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
GFQVQHSPMW DDPGSLHNFH QNYVATTHMI EQRKTPVSRL SLFSFKQSPP GTPVSSCQMR FDGPLHVPMN PEPAGSHHVV DGQTFAVPNP IRKPASMGFP
Target Information
The Nuclear receptor related 1 protein (Nurr1), also known as NR4A2 (nuclear receptor subfamily 4, group A, member 2), is encoded by the NR4A2 gene in humans.
NURR1 is a member of the nuclear receptor family of intracellular transcription factors and plays a key role in maintaining the dopaminergic system of the brain.
Mutations in this gene are associated with disorders related to dopaminergic dysfunction, including Parkinson’s disease, schizophrenia, and manic depression.
Misregulation of this gene may be linked to rheumatoid arthritis. Four transcript variants encoding distinct isoforms have been identified, with additional splice variants possibly existing.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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