Thermo Fisher Scientific NUP98 Polyclonal Antibody, MaxPab
Thermo Fisher Scientific의 NUP98 Polyclonal Antibody는 인간 NUP98 단백질을 인식하는 Rabbit IgG 항체로, Western blot 등에 사용됩니다. 고순도 Affinity chromatography로 정제되었으며, PBS(pH 7.4) 용액 상태로 제공됩니다. 연구용으로만 사용 가능합니다.
- 카탈로그번호
- H00004928-D01P
- 판매단위
- pk
카탈로그
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Thermo Fisher Scientific NUP98 Polyclonal Antibody, MaxPab
Applications
- Western Blot (WB)
Tested Dilution: 1–5 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | NUP98 (AAH12906.1, 1–606 a.a) full-length human protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
MKLYQTPLEL KLKHSTVHVD ELCPLIVPNL GVAVIHDYAD WVKEASGDLP EAQIVKHWSL TWTLCEALWG HLKELDSQLN EPREYIQILE RRRAFSRWLS CTATPQIEEE VSLTQKNSPV EAVFSYLTGK RISEACSLAQ QSGDHRLALL LSQFVGSQSV RELLTMQLVD WHQLQADSFI QDERLRIFAL LAGKPVWQLS EKKQINVCSQ LDWKRSLAIH LWYLLPPTAS ISRALSMYEE AFQNTSDSDR YACSPLPSYL EGSGCVIAEE QNSQTPLRDV CFHLLKLYSD RHYDLNQLLE PRSITADPLD YRLSWHLWEV LRALNYTHLS AQCEGVLQAS YAGQLESEGL WEWAIFVLLH IDNSGIREKA VRELLTRHCQ LLETPESWAK ETFLTQKLRV PAKWIHEAKA VRAHMESDKH LEALCLFKAE HWNRCHKLII RHLASDAIIN ENYDYLKGFL EDLAPPERSS LIQDWETSGL VYLDYIRVIE MLRHIQQVDC SGNDLEQLHI KVTSLCSRIE QIQCYSAKDR LAQSDMAKRV ANLLRVVLSL HHPPDRTSDS TPDPQRVPLR LLAPHIGRLP MPEDYAMDEL RSLTQSYLRE LAVGSL
Target Information
Signal-mediated nuclear import and export proceed through the nuclear pore complex (NPC), which consists of approximately 50 unique proteins known as nucleoporins. The 98 kDa nucleoporin is generated by proteolytic cleavage of a 186 kDa precursor protein, resulting in 98 kDa and 96 kDa nucleoporins localized to the nucleoplasmic side of the NPC.
Rat studies indicate that the 98 kDa nucleoporin functions as a docking site nucleoporin for transport substrates. The human NUP98 gene is implicated in chromosomal translocations in acute myelogenous leukemia (AML) and T-cell acute lymphocytic leukemia (T-ALL). It resides within the imprinted gene domain of 11p15.5, a region associated with tumor-suppressor activity. Alterations in this region have been linked to Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and various cancers. Multiple transcript variants exist due to alternative splicing.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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