Thermo Fisher Scientific Phospho-PDPK1 (Ser241) Polyclonal Antibody
PDPK1의 Ser241 인산화 상태를 특이적으로 인식하는 Rabbit Polyclonal 항체. Western blot 및 IHC(Paraffin)에서 검증됨. Human, Mouse, Rat 반응성. 1 mg/mL 농도의 액상 형태로 제공되며, -20°C에서 보관.
- 카탈로그번호
- PA5104700
- 판매단위
- pk
카탈로그
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human PDPK1 (Accession O15530), corresponding to amino acid residues around phosphorylated Ser241. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816173 |
Product Specific Information
This antibody detects endogenous levels of PDPK1 only when phosphorylated at Serine 241.
Target Information
PDPK1 (3-Phosphoinositide Dependent Protein Kinase 1) phosphorylates AGC kinases and activates conventional PKC and PKC zeta via phosphorylation of threonine residues in the activation loop. It also phosphorylates Protein Kinase B (PKB/Akt) at threonine 308 in the presence of phosphatidylinositol-3,4,5-trisphosphate. Active Akt inactivates Glycogen Synthase Kinase 3 (GSK3), leading to glycogen synthase activation and enhanced glycogen synthesis. Due to its role in insulin-induced glycogen synthesis and PKC activation, PDPK1 is an important target in metabolic research.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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