Thermo Fisher Scientific Phospho-Survivin (Thr117) Polyclonal Antibody
Phospho-Survivin (Thr117) 특이적 폴리클로날 항체로, 인간·마우스·랫트 시료에서 사용 가능. Western blot, IHC, ICC/IF에 적합하며, 세포 분열 및 생존 연구에 활용. 고순도 정제 및 안정적 보관 용이.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human BIRC5 (Accession O15392), corresponding to amino acid residues around phosphorylated Thr117 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816172 |
Product Specific Information
This antibody detects endogenous levels of Survivin only when phosphorylated at Threonine 117.
Target Information
Survivin (IAP4) is the smallest member of the Inhibitors of Apoptosis Protein (IAP) family. These proteins are involved in cell signaling, cell division, and metabolism, and are differentially expressed in most human cancers but not in normal tissues. Survivin contains a single BIR domain and lacks a C-terminal RING finger domain. Expression is high during fetal development and in tumors, but low in adult tissues.
Survivin is expressed in the G2/M phase of the cell cycle and associates with mitotic spindle microtubules. Disruption of this interaction increases caspase-3 activity and apoptosis during mitosis. It is also expressed in brain tissues following traumatic injury, potentially influencing neural cell proliferation. Multiple transcript variants exist for this gene, with at least three fully characterized.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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