Thermo Fisher Scientific NCOA2/SRC2 Polyclonal Antibody
Rabbit polyclonal antibody targeting human NCOA2/SRC2 for WB, IHC, and IP applications. Recognizes C-terminal region (1400–1464). Supplied as unconjugated liquid form at 1 mg/mL. Recommended storage at 4°C; shelf life 1 year.
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Thermo Fisher Scientific NCOA2/SRC2 Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunohistochemistry (IHC) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500–1:2,000 |
| Immunoprecipitation (IP) | 1–4 µg/mg lysate |
Product Specifications
| Specification | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 1400 and the C-terminus (residue 1464) of human Nuclear Receptor Coactivator 2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- For IHC, epitope retrieval with citrate buffer (pH 6.0) is recommended for FFPE tissue sections
Target Information
SRC2 (Steroid Receptor Coactivator 2), also known as Nuclear Receptor Coactivator 2 (NCOA2 or TIF2), facilitates the function of nuclear hormone receptors. These receptors act as conditional transcription factors that regulate gene expression involved in cell growth, development, and homeostasis.
Members of the nuclear hormone receptor superfamily include steroid and class II nuclear receptors, characterized by three domains:
- N-terminal transcriptional activation domain
- Central DNA-binding domain
- C-terminal hormone-binding domain
Before hormone binding, steroid receptors remain inactive in complexes with heat-shock proteins. Hormone binding triggers conformational changes, enabling receptor dimerization, DNA enhancer binding, and transcription modulation. Transcriptional coactivator proteins like SRC2 are required to initiate transcriptional stimulation.
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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