Thermo Fisher Scientific NCOA2/SRC2 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:1,000–1:10,000

Immunoprecipitation (IP)

• Tested Dilution: 1–4 µg/mg lysate

Product Specifications

Product Specific Information

• Recommended shelf life: 1 year from date of receipt
• Based on 100% sequence identity, this antibody is predicted to react with Rat

Target Information

SRC2 (steroid receptor coactivator 2), also known as NCOA2 or TIF2, is a coactivator for nuclear hormone receptors. These receptors function as conditional transcription factors that regulate gene expression involved in cell growth, development, and homeostasis.
Nuclear hormone receptors typically possess three domains:

1. N-terminal transcriptional activation domain
2. Central DNA-binding domain
3. C-terminal hormone-binding domain

Prior to hormone binding, steroid receptors remain inactive in complexes with heat-shock proteins. Hormone binding induces conformational changes that allow receptor activation, DNA binding, and transcription modulation. Coactivator proteins like SRC2 are essential for transcription initiation after receptor activation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.