Thermo Fisher Scientific NCOA2/SRC2 Polyclonal Antibody
NCOA2/SRC2 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체로, WB, IHC, IP 등 다양한 응용에 사용 가능. Human 및 Mouse 반응성. 항원 친화 크로마토그래피로 정제되었으며, 4°C에서 보관. 연구용 전용 제품.
- 카탈로그번호
- A300346A
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific NCOA2/SRC2 Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunohistochemistry (IHC) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500–1:2,000 |
| Immunoprecipitation (IP) | 1–4 µg/mg lysate |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 1400 and the C-terminus (residue 1464) of human Nuclear Receptor Coactivator 2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Phosphate/tris citrate, pH 7–8 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Application Note: For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.
Target Information
SRC2 (steroid receptor coactivator 2), also known as nuclear receptor coactivator 2 (NCOA2 or TIF2), functions as a coactivator for nuclear hormone receptors.
These receptors act as conditional transcription factors that regulate gene expression involved in cell growth, development, and homeostasis.
Members of this receptor family include steroid receptors and class II nuclear receptors, which share three structural domains:
- N-terminal transcriptional activation domain
- Central DNA-binding domain
- C-terminal hormone-binding domain
Before hormone binding, steroid receptors remain inactive in a complex with heat-shock proteins.
Hormone binding induces conformational changes, leading to dissociation from inhibitory complexes, dimerization, and binding to DNA enhancer elements to modulate gene transcription.
Transcriptional coactivator proteins such as SRC2 mediate transcription initiation following enhancer binding.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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