Thermo Fisher Scientific ASIC1 Polyclonal Antibody

Applications

Tested Application

• Western Blot (WB): 1:500–1:2,000

Product Specifications

Product Specific Information

Predicted to react with Mouse and Rat samples.

Target Information

This gene encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. Members of this family are amiloride-sensitive sodium channels with intracellular N and C termini, two hydrophobic transmembrane regions, and a large extracellular loop rich in cysteine residues with conserved spacing.
The encoded protein is expressed in most brain neurons and may function as an ion channel subunit. It forms a cation channel with high affinity for sodium, gated by extracellular protons and inhibited by amiloride. ASIC1 is permeable to Ca²⁺, Li⁺, and K⁺, and is expressed in dorsal root ganglia, sciatic nerves, olfactory bulb, neocortical and allocortical regions, hippocampal CA1–CA3 subfields, habenula, amygdala, cerebellar Purkinje and granule cells, and diffusely across basal ganglia, thalamic nuclei, substantia nigra, striatum, globus pallidus, hypothalamus, midbrain, pons, medulla, and choroid plexus.
Isoform 3 is expressed only in dorsal root ganglion, while isoform 1 is expressed in DRG, spinal cord, trigeminal ganglia, and trigeminal mesencephalic nucleus.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.