Thermo Fisher Scientific CaV3.1 Monoclonal Antibody (N178A/9)
CaV3.1 단백질을 특이적으로 검출하는 Mouse IgG1 단일클론 항체로, WB, IHC, ICC/IF에 적합합니다. Rat, Mouse, Human 시료 반응성이 있으며, Protein G 정제 및 PBS/glycerol buffer로 보관됩니다. Cav3.2와 교차 반응하지 않으며 연구용으로만 사용됩니다.
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Thermo Fisher Scientific CaV3.1 Monoclonal Antibody (N178A/9)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1:200 |
| Immunocytochemistry (ICC/IF) | 1:100 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | N178A/9 |
| Immunogen | Fusion protein amino acids 2052–2172 (cytoplasmic C-terminus) of mouse Cav3.1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2735141 |
Available Formats
Product Specific Information
- 1 µg/mL of MA5-27655 was sufficient for detection of Cav3.1 in 20 µg of rat brain membrane lysate using colorimetric immunoblot analysis and goat anti-mouse IgG:HRP as secondary antibody.
- Detects approximately <200 kDa.
- Does not cross-react with Cav3.2.
- This antibody was formerly sold as clone S178A-9.
Target Information
Voltage-dependent Ca²⁺ channels mediate Ca²⁺ entry into excitable cells in response to membrane depolarization. They participate in muscle contraction, hormone or neurotransmitter release, and gene expression.
Calcium channels are multimeric complexes composed of:
- Alpha-1 subunit
- Intracellular beta subunit
- Disulfide-linked alpha-2/delta subunit
- Transmembrane gamma subunit
Ca²⁺ currents are classified by biophysical and pharmacologic properties into L-, N-, T-, P-, Q-, and R-types.
T-type Ca²⁺ currents activate and inactivate rapidly at more negative membrane potentials. They enhance odor sensitivity by lowering spike generation thresholds in olfactory receptor cells (ORCs).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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