Thermo Fisher Scientific KCNQ4 Monoclonal Antibody (N43/6)
KCNQ4 단백질을 인식하는 Mouse Monoclonal Antibody (Clone N43/6). Western blot, IHC, ICC 등 다양한 응용에 사용 가능. Human, Mouse, Rat 반응성. 단백질 G 정제, PBS/glycerol buffer, -20°C 보관.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:1,000 |
| Immunohistochemistry (Frozen) (IHC-F) | 1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:100 |
| Antibody Microarray (AM) | Assay-dependent |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | N43/6 |
| Immunogen | Fusion protein corresponding to amino acids 2–77 of human KCNQ4 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2735246 |
Available Conjugated Formats
- APC (MA5-45411)
- FITC (MA5-45412)
- PE (MA5-45414)
- PerCP (MA5-45413)
- Request custom conjugation
Product Specific Information
1 µg/mL of MA5-27653 was sufficient for detection of KCNQ4 in 10 µg of COS-1 cell lysate transiently expressing KCNQ4 by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody. Detects approximately 77 kDa.
Target Information
The protein encoded by the KCNQ4 gene forms a potassium channel that plays a critical role in regulating neuronal excitability, particularly in sensory cells of the cochlea. The channel current is inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, an anti-convulsant drug. The encoded protein can form homomultimeric or heteromultimeric potassium channels with KCNQ3. Mutations in this gene cause nonsyndromic sensorineural deafness type 2, an autosomal dominant progressive hearing loss. Two transcript variants encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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