Thermo Fisher Scientific TRPC4 Monoclonal Antibody (S77-15)

Applications and Tested Dilutions

Product Specifications

Target Information

TRPC4 is a member of the canonical subfamily of transient receptor potential cation channels. It forms a non-selective calcium-permeable cation channel activated by Gq-coupled receptors and tyrosine kinases. TRPC4 plays roles in endothelial permeability, vasodilation, neurotransmitter release, and cell proliferation.
Single nucleotide polymorphisms in TRPC4 may be associated with generalized epilepsy with photosensitivity.
Alternatively spliced transcript variants encoding multiple isoforms have been observed for TRPC4.

The classical or canonical transient receptor potential (TRPC) channels are the subfamily most closely related to the founding member of the TRP family, the Drosophila TRP channel. TRPC channels have seven genes (TRPC1–7) encoding channel proteins.
Diseases associated with TRPC4 include Photosensitive Epilepsy.

CaV3.3 encodes the pore-forming alpha subunit of a voltage-gated calcium channel. This low voltage-activated, T-type calcium channel exhibits slower activation and inactivation compared to other T-type calcium channels.
CaV3.3 may be involved in calcium signaling in neurons. Alternate splicing results in multiple transcript variants.
Voltage-gated calcium channels (CaV) mediate calcium influx in response to depolarization and regulate intracellular processes such as contraction, secretion, neurotransmission, and gene expression.
Diseases associated with CACNA1I include Childhood Absence Epilepsy.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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