Thermo Fisher Scientific TIM3 Monoclonal Antibody (TI.H3)

Applications and Tested Dilution

Product Specifications

Product Specific Information

Reconstitute the lyophilized antibody with deionized water (or equivalent) to a final concentration of 0.5 mg/mL.

TIM-3 (T cell immunoglobulin and mucin domain-3) is a member of the TIM family of immune-regulating molecules. Its binding to Galectin-9 induces immunosuppressive functions that enhance immune tolerance and inhibit anti-tumor immunity.
GenScript Human TIM3 Antibody (TI.H3), mAb, Mouse is produced from the hybridoma formed by fusion of SP2/0 myeloma cells and B-lymphocytes obtained from mice immunized with recombinant human TIM3-Fc (2365-TM).

Target Information

TIM3 (Hepatitis A virus cellular receptor 2, HAVCR2, T-cell immunoglobulin, mucin-domain containing-3) is a 281-amino-acid, type I transmembrane glycoprotein expressed on terminally differentiated CD4⁺ Th1 and CD8⁺ Tc1 cells.
It consists of an IgV-like domain, a mucin-like extracellular domain, and a conserved tyrosine phosphorylation motif in the cytoplasmic region. TIM3 is involved in macrophage activation and autoimmune disease induction, downregulates Th1-mediated immune responses, and supports immune tolerance development.
Pathological significance has been linked to experimental autoimmune encephalomyelitis (EAE), a Th1-dependent autoimmune disease, where TIM3 enhances disease severity in mice.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.