Thermo Fisher Scientific TIM3 Monoclonal Antibody (TI.B2)

Thermo Fisher Scientific TIM3 Monoclonal Antibody (TI.B2)

Applications and Tested Dilutions

Product Specifications

Product Specific Information

Reconstitute the lyophilized antibody with deionized water (or equivalent) to a final concentration of 0.5 mg/mL.

TIM-3 (T cell immunoglobulin and mucin domain-3) is a member of the TIM family of immune regulating molecules. Its binding to Galectin-9 induces a range of immunosuppressive functions that enhance immune tolerance and inhibit anti-tumor immunity.
This monoclonal antibody (TI.B2) is produced from the hybridoma obtained by fusion of SP2/0 myeloma cells and B-lymphocytes from a mouse immunized with recombinant human TIM3-Fc (2365-TM).

Target Information

TIM3 (Hepatitis A virus cellular receptor 2, HAVCR2) is a 281-amino-acid, type I Th1-specific cell surface glycoprotein expressed on terminally differentiated CD4+ Th1 and CD8+ Tc1 cells.
It contains an IgV-like domain, a mucin-like domain in the extracellular region, and a conserved tyrosine phosphorylation motif in the cytoplasmic region.

TIM3 is involved in macrophage activation and autoimmune disease induction. It down-regulates aggressive Th1-mediated immune responses and contributes to immune tolerance development.
Pathological significance has been noted in Experimental Autoimmune Encephalomyelitis (EAE), a Th1-dependent autoimmune disease model, where TIM3 enhances disease severity in mice.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.