Thermo Fisher Scientific NCAM1 Monoclonal Antibody (OTI2F6), TrueMAB

Applications and Tested Dilutions

Product Specifications

Product Specific Information

For reconstitution, add 100 µL of distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

CD56 (NCAM, neural cell adhesion molecule) is a transmembrane glycoprotein of the immunoglobulin family that functions as an adhesive molecule and is widely expressed in the nervous system in isoforms of 120–180 kDa.
It is present on T cells and NK cells and plays a role in cell migration, axonal growth, pathfinding, and synaptic plasticity.
Polysialic modification reduces CD56-mediated adhesion. CD56 interacts with extracellular matrix components such as laminin and integrins.
It is expressed in neuroectodermal-derived tissues and tumors including retinoblastoma, medulloblastoma, astrocytoma, and neuroblastoma.
CD56 serves as a sensitive neuroendocrine marker for neuroendocrine and ovarian granulosa cell tumors.
Diseases associated with CD56 dysfunction include rabies and blastic plasmacytoid dendritic cell neoplasms.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.