Thermo Fisher Scientific TWIST2 Monoclonal Antibody (OTI1C4), TrueMAB
인간 TWIST2 단백질을 인식하는 Mouse IgG1 단일클론 항체로, Western blot에 최적화되어 있습니다. 동결건조 형태로 제공되며, PBS buffer와 trehalose를 포함합니다. 연구용으로만 사용되며 세포 분화 및 전사 억제 연구에 적합합니다.
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Applications
- Western Blot (WB)
Tested Dilution: 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1C4 |
| Immunogen | Full length human recombinant protein of human TWIST2 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of about 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
TWIST2 binds to the E-box consensus sequence (5'-CANNTG-3') as a heterodimer and inhibits transcriptional activation by MYOD1, MYOG, MEF2A, and MEF2C.
It represses expression of proinflammatory cytokines such as TNFA and IL1B, and is involved in postnatal glycogen storage and energy metabolism.
TWIST2 also inhibits premature or ectopic differentiation of preosteoblast cells during osteogenesis, possibly by altering internal signal transduction responses to external growth factors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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