Thermo Fisher Scientific Phospho-VAMP4 (Ser88) Polyclonal Antibody
VAMP4의 Ser88 인산화 부위를 특이적으로 인식하는 Rabbit Polyclonal 항체. Western blot 및 IHC(P) 검증 완료. Human, Mouse, Rat 반응성. PBS/glycerol buffer에 보관, -20°C 저장. 연구용으로만 사용 가능.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human VAMP4 (Accession O75379), corresponding to amino acid residues around phosphorylated Ser88 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816847 |
Product Specific Information
This antibody detects endogenous levels of VAMP4 only when phosphorylated at Ser88.
Target Information
The vesicle associated membrane proteins (VAMP) or synaptobrevins are calcium-binding proteins specific to eukaryotes. VAMPs, along with synaptosomal associated protein of 25 kDa (SNAP-25) and syntaxin, form the core complex of soluble NSF attachment protein receptor (SNARE) proteins that interact with soluble proteins N-ethylmaleimide-sensitive factor (NSF) and alpha-SNAP. These membrane-associated proteins play a key role in vesicle membrane fusion with the plasma membrane. The Clostridium tetani neurotoxin is a metalloprotease with specificity for VAMP. In Alzheimer’s disease, VAMP levels of all isoforms appear to be significantly lowered.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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