Thermo Fisher Scientific CHRM2 Polyclonal Antibody
CHRM2 단백질을 인식하는 Rabbit Polyclonal Antibody로, IHC(P)에서 4–8 µg/mL 농도로 사용 가능. 인간 시료에 반응하며, 항원 친화 크로마토그래피로 정제됨. 단기 4°C, 장기 -20°C 보관. 연구용으로만 사용.
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Applications and Tested Dilution
- Immunohistochemistry (Paraffin) (IHC (P)): 4–8 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic 19 amino acid peptide from 3rd cytoplasmic domain of human CHRM2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.1% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2550807 |
Product Specific Information
Percent identity with other species by BLAST analysis:
Human, Chimpanzee, Gorilla, Orangutan, Gibbon (100%); Marmoset, Rat, Dog, Hamster, Elephant, Pig (95%).
Target Information
Muscarinic cholinergic receptor 2 (CHRM2) is an acetylcholine receptor that may function as a presynaptic autoreceptor inhibiting acetylcholine release. The M2 receptor is also suggested to mediate smooth muscle contractility.
In Alzheimer’s disease (AD), selective loss of M2 subtype receptors occurs in cortical and hippocampal regions. Increased M2 receptor heterozygosity has been associated with depression in women.
The M2 receptor is expressed in various brain regions including the cerebellum, cerebral cortex, hippocampus, medulla, striatum, and thalamus, as well as in lung and prostate tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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