Thermo Fisher Scientific CD42b Monoclonal Antibody (AK2), Biotin
인간 CD42b 단백질을 인식하는 마우스 단클론 항체로, 비오틴으로 표지되어 있습니다. 유세포분석(Flow Cytometry)에 적합하며, 혈소판 활성화 및 응고 관련 연구에 유용합니다. 단백질 A로 정제되었으며, PBS와 BSA 완충액에 보관됩니다.
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Applications
- Flow Cytometry (Flow): Neat
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | AK2 |
| Immunogen | Human platelet glycoproteins (Target: CD42b, UniProt ID: P07359-1, Range: 1–652) |
| Conjugate | Biotin |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Protein A |
| Storage buffer | PBS with 1% BSA |
| Contains | 0.09% sodium azide |
| Storage conditions | 4°C |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2538067 |
Additional Formats
Product Specific Information
For FACS analysis, use 10 µL of the suggested working dilution to label 1×10⁶ cells in 100 µL.
Target Information
CD42b is a platelet activation marker involved in coagulation and platelet aggregation. It interacts with extracellular matrix and adhesion molecules, and its expression is regulated by VEGF and PDGF. CD42b forms part of the GPIb-IX-V receptor complex, essential for platelet-rich thrombus formation by binding to von Willebrand factor (VWF) at vascular injury sites. It also binds to thrombin, coagulation factors XI and XII, high molecular weight kininogen, TSP-1, integrin Mac-1, and P-selectin. CD42b expression occurs on platelets and megakaryocytes in bone marrow. Mutations in CD42b are associated with Bernard-Soulier syndrome and platelet-type von Willebrand disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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