Thermo Fisher Scientific CD42b Monoclonal Antibody (AK2), Biotin

Applications

• Flow Cytometry (Flow): Neat

Product Specifications

Additional Formats

• Unconjugated
• FITC
• PE
• Request custom conjugation

Product Specific Information

For FACS analysis, use 10 µL of the suggested working dilution to label 1×10⁶ cells in 100 µL.

Target Information

CD42b is a platelet activation marker involved in coagulation and platelet aggregation. It interacts with extracellular matrix and adhesion molecules, and its expression is regulated by VEGF and PDGF. CD42b forms part of the GPIb-IX-V receptor complex, essential for platelet-rich thrombus formation by binding to von Willebrand factor (VWF) at vascular injury sites. It also binds to thrombin, coagulation factors XI and XII, high molecular weight kininogen, TSP-1, integrin Mac-1, and P-selectin. CD42b expression occurs on platelets and megakaryocytes in bone marrow. Mutations in CD42b are associated with Bernard-Soulier syndrome and platelet-type von Willebrand disease.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.