Thermo Fisher Scientific beta Tubulin Polyclonal Antibody

Thermo Fisher Scientific beta Tubulin Polyclonal Antibody

Applications

• Western Blot (WB)
  Tested Dilution: 0.2–1 µg/mL

Product Specifications

Product Specific Information

• Immunogen sequence:
  YHGDSDLQLD RISVYYNEAT GGKYVPRAIL VDLEPGTMDS VRSGPFGQIF

• Storage Guidance:
  For short-term use, store at 2–8°C up to 1 week.
  For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

• Predicted Homology:
  Cow: 100% | Dog: 100% | Guinea Pig: 100% | Horse: 100% | Human: 100% | Mouse: 100% | Rabbit: 100% | Rat: 100% | Zebrafish: 100%

Target Information

Beta tubulins are one of two core protein families (alpha and beta tubulins) that heterodimerize and assemble to form microtubules. Beta-III tubulin is primarily expressed in neurons and may be involved in neurogenesis, axon guidance, and maintenance. Mutations in the beta tubulin gene are associated with congenital fibrosis of the extraocular muscles type 3. Beta-III tubulin was also detected in Sertoli cells of the testis and transiently in non-neuronal embryonic tissues.
Glutamate residues at the C-terminus of beta III tubulin can be glutamylated, though the precise function of such modifications is unclear. Tubulin is phosphorylated on Ser-172 by CDK1 during cell cycle progression, which inhibits tubulin incorporation into microtubules.
Microtubules, composed of alpha and beta tubulin dimers, are major cytoskeletal elements essential for chromosome segregation, intracellular transport, ciliary and flagellar motion, and structural support. Because beta-tubulin is ubiquitous in eukaryotic cells, it is frequently used as a loading control in protein detection assays such as Western blotting.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지

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