Thermo Fisher Scientific LEMD2 Polyclonal Antibody

Applications and Tested Dilution

• Western Blot (WB): 0.2–1 µg/mL

Product Specifications

Product Specific Information

• Immunogen sequence: QDMERYPYVG ILHVRDSLIP PQSRRRMKRV WDRAVEFLAS NESRIQTESH
• Storage guidance:
  • Short term: 2–8°C (up to 1 week)
  • Long term: -20°C in small aliquots to prevent freeze-thaw cycles
• Predicted homology:
  Cow 100%, Dog 100%, Guinea Pig 100%, Horse 100%, Human 100%, Mouse 100%, Rabbit 100%, Rat 100%, Yeast 89%

Target Information

The LEM (lamina-associated polypeptide–emerin–MAN1) domain is a motif found in lamin-interacting proteins of the inner nuclear membrane (INM) and nucleoplasm. LEMD2 (LEM domain-containing protein 2) is a lamina-associated protein in the INM that contributes to nuclear structure organization. It contains an N-terminal LEM motif, two transmembrane domains, and a MAN1-Src1p C-terminal (MSC) domain. LEMD2 is a truncated paralog of MAN1, lacking the MAN1-specific C-terminal RNA-recognition motif, but is similarly required for myogenic differentiation. Mutations in LEMD2 may be associated with muscle disease.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.