Thermo Fisher Scientific LEMD2 Polyclonal Antibody

Applications

• Western Blot (WB)
  Tested Dilution: 0.2–1 µg/mL

Product Specifications

Product Specific Information

Immunogen sequence:
SRRRMKRVWD RAVEFLASNE SRIQTESHRV AGEDMLVWRW TKPSSFSDSE

• For short-term use, store at 2–8°C up to 1 week.
• For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Predicted Homology:
Cow: 100% | Dog: 100% | Guinea Pig: 100% | Horse: 100% | Human: 100% | Mouse: 100% | Rat: 100%

Target Information

The LEM (lamina-associated polypeptide-emerin-MAN1) domain is a motif shared by a group of lamin-interacting proteins of the inner nuclear membrane (INM) and nucleoplasm.
LEMD2 (LEM domain-containing protein 2) is a lamina-associated protein in the INM involved in nuclear structure organization, containing an N-terminal LEM motif, two transmembrane domains, and a MAN1-Src1p C-terminal (MSC) domain.

LEMD2 is a truncated paralog of MAN1, lacking the MAN1-specific C-terminal RNA-recognition motif, but like MAN1 is required for myogenic differentiation.
Mutations in LEMD2 are thought to be among the possible causes of muscle disease.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.