Thermo Fisher Scientific GATM Polyclonal Antibody

Applications

Product Specifications

Product Specific Information

The antibody was affinity-purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen. Purity is >95% as determined by SDS-PAGE.

Target Information

AGAT (glycine amidinotransferase, also known as GATM or transamidinase) is a 423 amino acid protein belonging to the amidinotransferase family. It is encoded by a gene on human chromosome 15q21.1 and exists as three alternatively spliced isoforms. AGAT forms a homodimer, with equilibrium favoring a monomeric subunit structure. It localizes to mitochondrial inner membranes, peripheral membranes, and cytoplasm.

AGAT is biallelically expressed in placenta and fetal tissues and is also found in brain, heart, liver, lung, salivary gland, and skeletal muscle, with high expression in kidney. AGAT levels increase in myocardium during heart failure and decrease in inter-uterine growth restriction (IUGR)-associated placenta. It catalyzes the biosynthesis of guanidinoacetate, a precursor of creatine, essential for muscle energy metabolism. AGAT defects cause arginine:glycine amidinotransferase deficiency, an autosomal recessive disorder associated with developmental delay, mental retardation, speech disturbance, and brain creatine depletion. AGAT may play roles in embryonic and CNS development and in heart failure response via local creatine synthesis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.