Thermo Fisher Scientific GMPS Polyclonal Antibody
Rabbit polyclonal antibody recognizing human, mouse, and rat GMPS. Validated for WB and IP applications. Affinity-purified with >95% purity. Supplied in PBS with 50% glycerol, 0.02% sodium azide. For research use only.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunoprecipitation (IP) | 1:50–1:100 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant full-length Human GMPS (1–693 aa, UniProt ID: P49915-1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2720688 |
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by antigen-specific affinity chromatography. The purity is greater than 95% as determined by SDS-PAGE.
Target Information
GMPS is a transcription factor that plays a key role in defining the composition of the RNA polymerase II (RNAPII) elongation complex and in modulating the production of mature mRNA transcripts. It acts as an assembly factor to recruit various factors to the RNAPII elongation complex and is recruited via binding to the transcription elongation factor SUPT6H bound to the C-terminal domain (CTD) of the RNAPII subunit RPB1 (POLR2A). The SUPT6H:IWS1:CTD complex recruits mRNA export factors (ALYREF/THOC4, EXOSC10) and histone modifying enzymes (such as SETD2) to ensure proper mRNA splicing, efficient mRNA export, and elongation-coupled H3K36 methylation, a signature chromatin mark of active transcription.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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