Thermo Fisher Scientific STAT5 beta Recombinant Rabbit Monoclonal Antibody (13H20L4)
STAT5 beta 단백질을 표적하는 재조합 토끼 모노클로날 항체로, Western blot, IHC, ICC, ChIP 등에 적합. 높은 특이성과 재현성을 제공하며, 동물 유래 성분이 없는 포뮬레이션. 장기 보관 시 -20°C에서 안정적으로 유지.
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- pk
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Thermo Fisher Scientific STAT5 beta Recombinant Rabbit Monoclonal Antibody (13H20L4)
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 2–5 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:10–1:50 |
| Immunocytochemistry (ICC/IF) | 2–4 µg |
| ChIP assay (ChIP) | 3 µg |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Expression System | Expi293 |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 13H20L4 |
| Immunogen | Peptide corresponding to amino acids 49–57 of human STAT5b (region has no sequence homology with other STATs) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term; for long-term storage, store at -20°C, avoiding freeze/thaw cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2532392 |
Product Specific Information
- Intact IgG appears on a non-reducing gel as a ~150 kDa band and upon reduction generates a ~25 kDa light chain and a ~50 kDa heavy chain.
- Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems developed by cloning antibody DNA sequences from immunoreactive rabbits.
- Advantages include:
- Improved specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulation
- Broader immunoreactivity due to larger rabbit immune repertoire
Target Information
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by receptor-associated kinases, forming homo- or heterodimers that translocate to the nucleus to act as transcription activators.
STAT5 beta mediates signaling triggered by ligands such as IL2, IL4, CSF1, and growth hormones, and is involved in processes like TCR signaling, apoptosis, mammary gland development, and liver gene expression dimorphism.
This gene can fuse with the RARA gene in some acute promyelocytic leukemias (APLL), and dysregulation of its pathway may contribute to disease development.
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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(이미지 파일: 701109_STAT5_beta_P51692-1_Rabbit.svg, 701109_STAT5_beta_P51692-1_Rabbit_PDP.jpeg)
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