Thermo Fisher Scientific IFN gamma Recombinant Rabbit Monoclonal Antibody (18H3L15)
Thermo Fisher Scientific의 IFN gamma Recombinant Rabbit Monoclonal Antibody (18H3L15)은 Rat IFNγ 단백질을 인식하는 고특이성 항체입니다. Western blot에 최적화되어 있으며, 재조합 단일클론 항체로 일관된 생산성과 높은 민감도를 제공합니다. 단기 4°C, 장기 -20°C 보관 권장.
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Applications
- Western Blot (WB): 0.1–3 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | Expi293 |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 18H3L15 |
| Immunogen | Recombinant protein corresponding to amino acids 23–156 of rat interferon gamma |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2532402 |
Product Specific Information
Intact IgG appears on a non-reducing gel as a ~150 kDa band and upon reduction generates a ~25 kDa light chain band and a ~50 kDa heavy chain.
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning the specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select the best candidates for production.
Advantages of recombinant rabbit monoclonal antibodies include:
- Better specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulations
- Broader immunoreactivity to diverse targets due to larger rabbit immune repertoire
Target Information
IFN gamma (Interferon gamma, Type II interferon) is a macrophage activation factor and immune interferon produced primarily by T-lymphocytes and natural killer cells in response to antigens and cytokines. It is a dimeric glycoprotein consisting of two 146 amino acid subunits (~45 kDa homodimer).
On SDS-PAGE, IFN gamma appears as a combination of 25, 20, and minor 15.5 kDa bands due to differential glycosylation. Its biological activity is species-specific; human IFN gamma does not cross-react with mouse IFN gamma.
Functions include:
- Antiviral and tumor antiproliferative activity
- Induction of class I and II MHC
- Macrophage activation
- Enhanced immunoglobulin secretion by B lymphocytes
Activation occurs through IFN gamma receptor I and II, triggering the JAK-STAT pathway. IFN gamma shows ~40% sequence homology between human and mouse forms. It is upregulated by IL2, FGF basic, and EGF, and downregulated by vitamin D3 or DMN. Gene mutations are associated with aplastic anemia.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일명: 701125_IFN_gamma_P01581-1_Rabbit.svg, 701125_IFN_gamma_P01581-1_Rabbit_PDP.jpeg)
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