Thermo Fisher Scientific CD55 Monoclonal Antibody (Bu14), FITC

Applications

• Flow Cytometry (Flow): Neat–1:10

Product Specifications

Additional Formats

• Unconjugated
• Request custom conjugation

Product Specific Information

For FACS analysis, use 10 µL of the suggested working dilution to label 1×10⁶ cells in 100 µL.
Mouse anti-Human CD55 antibody, clone Bu14 recognizes human CD55, also known as Decay Accelerating Factor (DAF).

Target Information

CD55 (decay-accelerating factor, DAF) is a GPI-anchored membrane glycoprotein that protects autologous cells from the classical and alternative pathways of the complement cascade.
Interactions between CD55 and CD97 are involved in T cell regulation, and CD55 can regulate complement when bound to CD97.
In tumors, CD55 promotes neoangiogenesis, tumorigenesis, invasiveness, and evasion of apoptosis.

CD55 is a 70 kDa glycoprotein in erythrocytes anchored by a glycosylphosphatidylinositol tail. In other cells, CD55 appears larger due to O-glycan content. It binds activated C4b or C3b complement fragments, preventing assembly and accelerating decay of complement pathways.
CD55 carries the Cromer-related blood group antigens. Two alternatively spliced transcripts encode either a membrane-bound or soluble protein, with the membrane form being predominant.
CD55 has been studied for its role in prostate cancer growth and survival.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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