
Thermo Fisher Scientific TIMP2 (Tissue Inhibitor of Metalloproteinase 2) Monoclonal Antibody (TIMP2, 2044)
인체 TIMP2 단백질을 인식하는 Mouse IgG1 단클론 항체로, IHC(P) 및 Peptide Array에 사용 가능. Recombinant TIMP2(aa 48-220)로 면역생성. Protein A/G로 정제된 액상 항체이며, -20°C 이하에서 보관. 세포외기질 분해효소 억제 연구에 적합.
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Thermo Fisher Scientific TIMP2 Monoclonal Antibody (TIMP2, 2044)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1–2 µg/mL |
| Peptide Array (Array) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | TIMP2, 2044 |
| Immunogen | Recombinant human TIMP2 protein fragment (aa 48–220) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C or -80°C if preferred |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Tested in direct ELISA (use antibody at 2–4 µg/mL for coating).
- For immunohistochemistry (PFA-fixed): incubate antibody for 30 minutes at room temperature.
- For formalin-fixed tissues, heat sections in 10 mM Tris with 1 mM EDTA (pH 9.0) at 95°C for 45 minutes, then cool at room temperature for 20 minutes.
Target Information
TIMP-1 and TIMP-2 are inhibitors of the matrix metalloproteinase family, playing a crucial role in maintaining connective tissue integrity.
TIMP-2 binds strongly to both latent and active forms of 72 kDa Type IV collagenase (MMP-2, gelatinase A) and also to the active form of 92 kDa Type IV collagenase (MMP-9, gelatinase B).
It inhibits the proteolytic invasiveness of tumor cells and normal placental trophoblast cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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