Thermo Fisher Scientific CHMP3 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

Immunogen sequence:
VNEWSLKIRK EMRVVDRQIR DIQREEEKVK RSVKDAAKKG QKDVCIVLAK EMIRSRKA

Target Information

Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) generated by invagination and scission from the limiting membrane of the endosome and are delivered to lysosomes for degradation of membrane proteins, lysosomal enzymes, and lipids.
The MVB pathway requires sequential function of ESCRT-0, -I, -II, and -III complexes. ESCRT-III proteins dissociate from the invaginating membrane before ILV release. The ESCRT machinery also functions in membrane fission events such as cytokinesis and budding of enveloped viruses (HIV-1 and other lentiviruses).
ESCRT-III proteins mediate vesicle extrusion and/or membrane fission, possibly with AAA ATPase VPS4. Selectively binds to phosphatidylinositol 3,5-bisphosphate [PtdIns(3,5)P2] and PtdIns(3,4)P2 over other phosphoinositides. Involved in late stages of cytokinesis and endosomal sorting/trafficking of EGF receptor. Isoform 2 prevents stress-mediated cell death and accumulation of reactive oxygen species when expressed in yeast cells.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.