Thermo Fisher Scientific CHMP3 Polyclonal Antibody
Thermo Fisher Scientific의 CHMP3 Polyclonal Antibody는 인간 CHMP3 단백질을 인식하는 토끼 유래 IgG 항체입니다. Western blot 및 IHC(P)에서 검증되었으며, 항원 친화 크로마토그래피로 정제되었습니다. ESCRT-III 복합체 연구에 적합합니다.
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- PA584924
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- pk
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500–1:1,000 | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human CHMP3. Recombinant protein control fragment (Product #RP-108612). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2792073 |
Product Specific Information
Immunogen sequence:
VNEWSLKIRK EMRVVDRQIR DIQREEEKVK RSVKDAAKKG QKDVCIVLAK EMIRSRKA
Target Information
Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) generated by invagination and scission from the limiting membrane of the endosome and are delivered to lysosomes for degradation of membrane proteins, lysosomal enzymes, and lipids.
The MVB pathway requires sequential function of ESCRT-0, -I, -II, and -III complexes. ESCRT-III proteins dissociate from the invaginating membrane before ILV release. The ESCRT machinery also functions in membrane fission events such as cytokinesis and budding of enveloped viruses (HIV-1 and other lentiviruses).
ESCRT-III proteins mediate vesicle extrusion and/or membrane fission, possibly with AAA ATPase VPS4. Selectively binds to phosphatidylinositol 3,5-bisphosphate [PtdIns(3,5)P2] and PtdIns(3,4)P2 over other phosphoinositides. Involved in late stages of cytokinesis and endosomal sorting/trafficking of EGF receptor. Isoform 2 prevents stress-mediated cell death and accumulation of reactive oxygen species when expressed in yeast cells.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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