Thermo Fisher Scientific UFD1L Polyclonal Antibody
Thermo Fisher Scientific의 UFD1L Polyclonal Antibody는 인간 UFD1L 단백질을 인식하는 토끼 유래 IgG 항체로, ICC/IF 등 연구용 분석에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며 PBS 기반 버퍼에 보관됩니다. 단백질 분해 경로 연구에 활용됩니다.
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Applications
Immunocytochemistry (ICC/IF)
- Tested Dilution: 0.25–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human UFD1L (UniProt ID: Q92890-2, antigen range: 1–58, antigen length: 307) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.05 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2792074 |
Product Specific Information
Immunogen sequence:
MFSFNMFDHP IPRVFQNRFS TQYRCFSVSM LAGPNDRSDV EKGGKIIMPP SALDQLSR
Target Information
Ubiquitin-mediated proteolysis requires the transfer of ubiquitin (Ub) to lysine groups on selected cellular proteins, facilitating degradation by the 26S proteasome. Ub-fusions are processed by Ub-specific proteases (UBps) or the Ub-fusion degradation (UFD) pathway. UFD proteins preferentially cleave Ub-conjugated proteins with amino acid substitutions at the C-terminal glycine residue.
Human UFD1L, a homolog of yeast UFD1, modulates degradation of Ub-fusions with substitutions at Gly76 through selective multiubiquitination. Mutations in UFD1 are associated with CATCH22 syndrome, characterized by cardiac defects, cleft palate, and hypocalcemia, indicating a role in developmental proteolytic processes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
- PA5-84925_UFD1L_Q92890-2_Rabbit.svg
- PA5-84925_UFD1L_Q92890-2_Rabbit_PDP.jpeg
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