Thermo Fisher Scientific ICOS Monoclonal Antibody (OTI5G8)

Applications

• Flow Cytometry (Flow): 1:100–1:400 dilution

Product Specifications

Product Specific Information

For reconstitution, add 100 µL of distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

ICOS (CD278) encodes a protein that belongs to the CD28 and CTLA-4 cell-surface receptor family. It functions as a homodimer and plays a crucial role in:

• Cell-cell signaling
• Immune response regulation
• Cell proliferation control

Mutations or dysregulation of ICOS are associated with disorders such as Common Variable Immunodeficiency (CVID).

For Research Use Only. Not for use in diagnostic procedures or resale without authorization.