Thermo Fisher Scientific USP25 Polyclonal Antibody
USP25 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB 및 ELISA에 적합합니다. 인간, 생쥐, 랫트 반응성을 가지며, 고순도 친화 크로마토그래피로 정제되었습니다. PBS와 글리세롤 기반 저장 버퍼를 사용하며 -20°C에서 보관합니다.
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Thermo Fisher Scientific USP25 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:100–1:500 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 1–230 of human USP25 (NP_0375283) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.32 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2805048 |
Product Specific Information
- Immunogen sequence: MTVEQNVLQQ SAAQKHQQTF LNQLREITGI NDTQILQQAL KDSNGNLELA VAFLTAKNAK TPQQEETTYY QTALPGNDRY ISVGSQADTN VIDLTGDDKD DLQRAIALSL AESNRAFRET GITDEEQAIS RVLEASIAEN KACLKRTPTE VWRDSRNPYD RKRQDKAPVG LKNVGNTCWF SAVIQSLFNL LEFRRLVLNY KPPSNAQDLP RNQKEHRNLP FMRELRYLFA
- Positive Samples: HL-60, HT1080, U251MG, HeLa, SKOV3, Mouse testis, Rat testis
- Cellular Location: Cytoplasm, Nucleus
Target Information
Modification of target proteins by ubiquitin participates in a wide array of biological functions. Proteins destined for degradation or processing via the 26S proteasome are coupled to multiple copies of ubiquitin. Attachment of ubiquitin or ubiquitin-related molecules may also result in changes in subcellular distribution or modification of protein activity.
Deubiquitination is catalyzed by deubiquitinating enzymes, which fall into four distinct families:
- Ubiquitin C-terminal hydrolases
- Ubiquitin-specific processing proteases (USPs)
- OTU-domain ubiquitin-aldehyde-binding proteins
- Jab1/Pad1/MPN-domain-containing metallo-enzymes
Among these, USPs are the most widespread deubiquitinating enzymes across evolution, releasing ubiquitin from conjugated proteins. They contain conserved catalytic Cys and His boxes with variable N- and C-terminal extensions for substrate recognition and protein interactions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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