Thermo Fisher Scientific USP25 Polyclonal Antibody

Thermo Fisher Scientific USP25 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Immunogen sequence: MTVEQNVLQQ SAAQKHQQTF LNQLREITGI NDTQILQQAL KDSNGNLELA VAFLTAKNAK TPQQEETTYY QTALPGNDRY ISVGSQADTN VIDLTGDDKD DLQRAIALSL AESNRAFRET GITDEEQAIS RVLEASIAEN KACLKRTPTE VWRDSRNPYD RKRQDKAPVG LKNVGNTCWF SAVIQSLFNL LEFRRLVLNY KPPSNAQDLP RNQKEHRNLP FMRELRYLFA
• Positive Samples: HL-60, HT1080, U251MG, HeLa, SKOV3, Mouse testis, Rat testis
• Cellular Location: Cytoplasm, Nucleus

Target Information

Modification of target proteins by ubiquitin participates in a wide array of biological functions. Proteins destined for degradation or processing via the 26S proteasome are coupled to multiple copies of ubiquitin. Attachment of ubiquitin or ubiquitin-related molecules may also result in changes in subcellular distribution or modification of protein activity.

Deubiquitination is catalyzed by deubiquitinating enzymes, which fall into four distinct families:

1. Ubiquitin C-terminal hydrolases
2. Ubiquitin-specific processing proteases (USPs)
3. OTU-domain ubiquitin-aldehyde-binding proteins
4. Jab1/Pad1/MPN-domain-containing metallo-enzymes

Among these, USPs are the most widespread deubiquitinating enzymes across evolution, releasing ubiquitin from conjugated proteins. They contain conserved catalytic Cys and His boxes with variable N- and C-terminal extensions for substrate recognition and protein interactions.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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