Thermo Fisher Scientific UHRF1 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 139-298 of human UHRF1 (NP_0374143) if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:UHRF1,uniProtId:Q96T88-1,ncbiNodeId:9606,antigenRange:139-298,antigenLength:793,antigenImageFileName:PA5-88643_UHRF1_Q96T88-1_Rabbit.svg,antigenImageFileNamePDP:PA5-88643_UHRF1_Q96T88-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

8.92 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2805049

Product Specific Information

Immunogen sequence: MWDETELGLY KVNEYVDARD TNMGAWFEAQ VVRVTRKAPS RDEPCSSTSR PALEEDVIYH VKYDDYPENG VVQMNSRDVR ARARTIIKWQ DLEVGQVVML NYNPDNPKER GFWYDAEISR KRETRTAREL YANVVLGDDS LNDCRIIFVD EVFKIERPGE; Positive Samples: Mouse brain; Cellular Location: Nucleus

Target Information

This gene encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases. The protein binds to specific DNA sequences, and recruits a histone deacetylase to regulate gene expression. Its expression peaks at late G1 phase and continues during G2 and M phases of the cell cycle. It plays a major role in the G1/S transition by regulating topoisomerase IIalpha and retinoblastoma gene expression, and functions in the p53-dependent DNA damage checkpoint. Multiple transcript variants encoding different isoforms have been found for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.