Thermo Fisher Scientific UHRF1 Polyclonal Antibody
Thermo Fisher Scientific의 UHRF1 Polyclonal Antibody는 마우스 시료에 반응하는 Rabbit IgG 항체로, Western blot 및 ELISA에 적합합니다. 액상 형태이며, 고순도 친화 크로마토그래피로 정제되었습니다. 세포핵 내 UHRF1 단백질 검출에 활용됩니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
ELISA
- Tested Dilution: 1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 139–298 of human UHRF1 (NP_0374143) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 8.92 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2805049 |
Product Specific Information
- Immunogen sequence: MWDETELGLY KVNEYVDARD TNMGAWFEAQ VVRVTRKAPS RDEPCSSTSR PALEEDVIYH VKYDDYPENG VVQMNSRDVR ARARTIIKWQ DLEVGQVVML NYNPDNPKER GFWYDAEISR KRETRTAREL YANVVLGDDS LNDCRIIFVD EVFKIERPGE
- Positive Samples: Mouse brain
- Cellular Location: Nucleus
Target Information
This gene encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases. The protein binds to specific DNA sequences and recruits a histone deacetylase to regulate gene expression. Its expression peaks at late G1 phase and continues during G2 and M phases of the cell cycle. It plays a major role in the G1/S transition by regulating topoisomerase IIalpha and retinoblastoma gene expression and functions in the p53-dependent DNA damage checkpoint. Multiple transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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