Thermo Fisher Scientific CD61/Integrin 3/Platelet Glycoprotein IIIa Recombinant Rabbit Monoclonal Antibody (ITGB3, 2166R)
Recombinant rabbit monoclonal antibody against CD61/Integrin β3 (ITGB3). Human reactive, suitable for IHC (paraffin). High purity, liquid form, 200 µg/mL concentration. For research use only.
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Applications
- Immunohistochemistry (Paraffin) (IHC (P)): 1–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host/Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | ITGB3, 2166R |
| Immunogen | Recombinant human ITGB3 protein fragment (aa 385–490) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage conditions | 4°C |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Immunohistochemistry (PFA fixed): Incubate antibody for 30 minutes at room temperature.
- Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 minutes at 95°C, followed by cooling at room temperature for 20 minutes.
Target Information
CD61 (GPIIIa, ITGB3) is a glycoprotein found on megakaryocytes, platelets, and their precursors. It plays a key role in platelet aggregation and serves as a receptor for fibrinogen, fibronectin, von Willebrand factor, and vitronectin.
CD61 is a 105 kDa glycoprotein that associates with alpha IIb integrin (CD41) or alpha V integrin (CD51) at the cell surface. It is expressed on platelets, megakaryocytes, endothelial cells, monocytes, and osteoclasts.
CD61 participates in cell adhesion and cell-surface mediated signaling.
Diseases associated with CD61 dysfunction include Glanzmann Thrombasthenia and Platelet type-16 Bleeding Disorder.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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