Thermo Fisher Scientific FGG Monoclonal Antibody (OTI2D2), TrueMAB

Applications and Tested Dilutions

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

The FGG gene encodes the gamma component of fibrinogen, a blood-borne glycoprotein composed of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin, the major component of blood clots.
Cleavage products of fibrinogen and fibrin also regulate cell adhesion and spreading, exhibit vasoconstrictor and chemotactic activities, and act as mitogens for various cell types.
Mutations in this gene are associated with disorders such as dysfibrinogenemia, hypofibrinogenemia, and thrombophilia.
Alternative splicing results in two transcript variants encoding different isoforms.

For Research Use Only. Not for use in diagnostic procedures or resale without express authorization.