Thermo Fisher Scientific PD-L1 Monoclonal Antibody (OTI2B12), TrueMAB

Applications

• Western Blot (WB): Tested dilution 1:4,000

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

Programmed death receptor ligand 1 (PD-L1, also known as B7-H1) is a member of the B7 family.
It binds to the programmed death receptor 1 (PD-1), which negatively regulates T-cell receptor (TCR) signaling.
Upon PD-L1 binding, TCR-mediated proliferation and cytokine production decrease.
PD-L1 expression is abundant in many murine and human cancers and can be upregulated by IFN-γ stimulation, suggesting its role in tumor immune evasion.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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