Thermo Fisher Scientific FGFR2 Polyclonal Antibody
FGFR2 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, Human 및 Mouse 반응성. Western blot, IHC에 적합하며 FGFR1/FGFR3 교차반응 없음. 항원 친화 크로마토그래피 정제, 1.3 mg/mL 농도, PBS/BSA 버퍼에 보관.
- 카탈로그번호
- PA124763
- 판매단위
- pk
카탈로그
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 0.25–0.5 µg/mL | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 2–4 µg/mL | View 1 publication |
| Immunoprecipitation (IP) | – | View 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Mouse, Non-human primate |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide conjugated to KLH by a Glutaraldehyde linker, corresponding to residues K(809)-T(821) of the cytoplasmic region of Human FGFR2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.3 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 1% BSA |
| Contains | 15 mM sodium azide |
| Storage Conditions | Store at 4°C short term; for long-term storage, store at -20°C, avoiding freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_780623 |
Product Specific Information
This antibody shows no cross-reactivity with FGFR1 or FGFR3.
PA1-24763 is expected to cross-react with mouse (92% conserved) and rat (92% conserved) due to sequence homology.
Target Information
FGFR2 is a member of the FGFR family of receptor tyrosine kinases. This family regulates cellular functions such as angiogenesis, mitogenesis, osteogenesis, myogenesis, carcinogenesis, differentiation, and tissue repair.
FGFR family members are implicated in diseases including cancer, rheumatoid arthritis, and diabetic retinopathy. Mutations in FGFR2 are associated with several syndromes such as Crouzon, Pfeiffer, Craniosynostosis, Apert, Jackson-Weiss, Beare-Stevenson cutis gyrata, Saethre-Chotzen, and syndromic craniosynostosis.
Multiple alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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