Thermo Fisher Scientific IL12RB1 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 0.1–0.2 µg/mL

ELISA

• Tested Dilution: 0.5–1 µg/mL

Product Specifications

Product Specific Information

• Recommended positive controls: recombinant human IL-12 R beta 1
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

The protein encoded by this gene is a type I transmembrane protein belonging to the hemopoietin receptor superfamily. It binds interleukin 12 with low affinity and is part of the IL12 receptor complex. This protein forms a disulfide-linked oligomer required for IL12 binding activity. Coexpression with IL12RB2 leads to high-affinity IL12 binding and signaling reconstitution. Lack of expression causes immunodeficiency in patients with severe mycobacterial and Salmonella infections. Two alternatively spliced transcript variants encoding distinct isoforms have been reported.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.