Thermo Fisher Scientific ATP1A1 Monoclonal Antibody (M7-PB-E9)

Thermo Fisher Scientific ATP1A1 Monoclonal Antibody (M7-PB-E9)

Applications and Tested Dilutions

Product Specifications

Additional Formats:

• Alexa Fluor 488
• Alexa Fluor 555
• Alexa Fluor 647
• Custom conjugation available upon request

Product Specific Information

MA3-928 detects sodium/potassium ATPase alpha from human, mouse, bovine, sheep, canine, chicken, and porcine tissues.
This antibody detects the alpha 3 isoform in rat only.

MA3-928 has been successfully used in Western blot, immunohistochemistry, immunoprecipitation, immunocytochemistry, immunofluorescence, and ELISA procedures.
By Western blot, this antibody detects an ~110 kDa protein representing alpha sodium/potassium ATPase from MDCK cell extract.
Immunohistochemical staining of alpha sodium/potassium ATPase in porcine heart yields a pattern consistent with plasma membrane localization.

The MA3-928 antigen is purified sheep kidney alpha sodium/potassium ATPase.
This antibody recognizes an epitope between amino acid residues 646–652 of the sheep kidney alpha sodium/potassium ATPase.

Target Information

The protein encoded by this gene belongs to the family of P-type cation transport ATPases and the subfamily of Na⁺/K⁺-ATPases.
Na⁺/K⁺-ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na⁺ and K⁺ ions across the plasma membrane.
These gradients are essential for osmoregulation, sodium-coupled transport of various molecules, and electrical excitability of nerve and muscle cells.
This enzyme consists of two subunits: a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta).
The catalytic subunit of Na⁺/K⁺-ATPase is encoded by multiple genes, and this gene encodes the alpha 1 subunit.
Multiple transcript variants encoding different isoforms have been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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