Thermo Fisher Scientific ALK Monoclonal Antibody (OTI3G1), TrueMAB
인간 ALK 단백질을 인식하는 Mouse IgG2a 단일클론 항체로, Western blot에 최적화됨. 뇌 발달 관련 ALK 단백질 연구 및 종양 관련 변이 분석에 적합. 액상 형태로 1 mg/mL 농도, PBS/BSA/glycerol 완충액에 보관.
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- TA801305
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Applications
- Western Blot (WB): Tested dilution 1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI3G1 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1300–1620 of human ALK produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Anaplastic Lymphoma Receptor Tyrosine Kinase (ALK) belongs to the insulin receptor superfamily and plays a vital role in brain development. Mutations, rearrangements, and amplifications in the ALK gene have been associated with tumors such as anaplastic large cell lymphoma, neuroblastoma, and non-small cell lung cancer. Chromosomal rearrangement commonly leads to the formation of a fusion gene between ALK and the nucleophosmin (NPM) gene, resulting in an oncogenic NPM-ALK fusion protein. ALK shares high sequence similarity with LTK and is important for neuronal development and signaling in the nervous system.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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