Thermo Fisher Scientific CD85j (ILT2) Polyclonal Antibody

Thermo Fisher Scientific CD85j (ILT2) Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• In direct ELISAs, approximately 25% cross-reactivity with recombinant human ILT4 and 15% cross-reactivity with recombinant human ILT5 are observed.
• Reconstitute at 0.2 mg/mL in sterile PBS.
• Endotoxin level is <0.10 EU per 1 µg of antibody by the LAL method.

Target Information

This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family located at chromosomal region 19q13.4.
The encoded protein belongs to the subfamily B class of LIR receptors, containing two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs).
It is expressed on immune cells, binds to MHC class I molecules on antigen-presenting cells, and transduces a negative signal that inhibits stimulation of an immune response.
This mechanism helps control inflammatory responses and cytotoxicity, focusing the immune response and limiting autoreactivity.
Multiple transcript variants encoding different isoforms have been identified for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.