Thermo Fisher Scientific LGMN Polyclonal Antibody

Applications

• Western Blot (WB)
  Tested Dilution: 0.2 µg/mL

Product Specifications

Product Specific Information

• In direct ELISAs, approximately 50% cross-reactivity with recombinant human Legumain is observed.
• Reconstitute at 0.2 mg/mL in sterile PBS.

Target Information

This gene encodes a cysteine protease that has a strict specificity for hydrolysis of asparaginyl bonds. The enzyme may be involved in processing bacterial peptides and endogenous proteins for MHC class II presentation in lysosomal/endosomal systems.
Activation is triggered by acidic pH and appears to be autocatalytic. Protein expression occurs after monocytes differentiate into dendritic cells. A fully mature enzyme is produced following lipopolysaccharide expression in mature dendritic cells.
Overexpression of this gene may be associated with the majority of solid tumor types. This gene has a pseudogene on chromosome 13. Several alternatively spliced transcript variants have been described, but the biological validity of only two has been determined.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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